Clinical Trials

Since 1988, when the U.S. Food and Drug Administration approved proton therapy to treat cancer patients, the medical community has been conducting clinical trials to investigate the use of protons in treating different types of cancer. Over the years, many patients have volunteered to take part in these clinical trials to help find improvements in fighting cancer with proton therapy.

As a dedicated provider of proton therapy, Oklahoma Proton Center is always looking for ways to improve the lives of our patients with cancer. Our team has made a commitment to participate in clinical trials to further our knowledge of the benefits of proton therapy in treating many tumor types. In addition, Oklahoma Proton Center continues to pioneer advancements in the use of proton therapy for treating cancer and other diseases.

What Are Clinical Trials?

Clinical trials are research studies that involve people. They are the final step in a long process that begins with research in a lab. Each study answers a specific set of scientific questions and explores better ways to prevent, screen for, diagnose, or treat a disease. Most cancer treatments used today are the results of past clinical trials. To better understand cancer clinical trials, please visit About Clinical Trials

What Are Protocols?

For every clinical trial, a protocol, or action plan, is prepared prior to conducting the trial. The protocol describes in detail what will be done in the study, how it will be conducted, and why each part of the study is necessary. Each study has its own rules about who can participate. For instance, some studies need patients with a certain condition, some need healthy people, and some need just men or just women.

Clinical Trials at this Oklahoma Proton Center
  • PCG REG001-09/NCT01255748: Patients Treated with Proton Therapy

    A registry trial to collect and analyze information from patients treated with proton therapy.

  • PPCR 12-103/NCT01696721: A Multi Center Registry of Pediatric Patients treated with Proton Radiation Therapy

    The goal of the Pediatric Proton Consortium Registry (PPCR) is to enroll children treated with proton radiation in the United States in order to describe the population that currently receives protons and better evaluate its benefits over other therapies. The data collected from this study will help facilitate research on proton beam radiation therapy and allow for collaborative research.

  • PCG GU002-10/NCT01230866: Low-risk Prostate Cancer (standard fractionation vs hypo-fractionation)

    A phase III, prospective, randomized trial comparing the effects (good and bad) on patients with low-risk prostate cancer by comparing the standard number of radiation treatments (44 treatments over 8.5-9 weeks) with a short course of radiation (5 treatments over 1-2 weeks) using higher radiation dose per treatment to see if the effects of the treatments are similar or better.

  • PCG GU003-10/NCT01492972: Intermediate-risk Prostate Cancer

    A phase III, prospective, randomized trial comparing the effects (good and bad) of hypofractionated proton therapy (28 treatments) with or without androgen suppression therapy on patients with intermediate-risk prostate cancer.

  • PCG BRE007-12/NCT01766297: Early Stage Breast Cancer

    A phase II, prospective, trial comparing the effects (good and bad) on women with early stage breast cancer using proton radiation therapy.

How Can I Find Clinical Trials?

You can search for more clinical trials by visiting

How Can I Participate in a Clinical Trial?

If you are interested in participating in a trial listed above, please contact a member of our research team and we will help you with next steps.

Oklahoma Proton Center
Kayla Tarrant, Clinical Research Coordinator
Phone: (405) 773-6775
Email address:

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